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EXED-005B
Exendin-3
His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Size:1.0mg
P1(RMB):1195
MW:4202.7
One letter sequence:HSDGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
Molecular Formula:C184H282N50O61S1
Description:A new member of the Glucagon superfamily that was originally isolated from the venom of the lizard, Heloderma Horridum. At low concentrations, it interacts with putative exendin receptors causing an increase in pancreatic acinar cAMP, while at higher concentrations it interacts with VIP receptors to stimulate an increase in cellular cAMP and amylase release.
Literature Reference:J. Eng et al., J. Biol. Chem., 267, 7402 (1992)
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