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UROC-001B
Urocortin, human
Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
Size:1.0mg
P1(RMB):1134
MW:4696.3
One letter sequence:DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2
Molecular Formula:C204H337N63O64
Description:Peptide that binds with high affinity to CRF receptor types 1, 2a & 2b, stimulates cAMP accumulation from cells transfected with those receptors, and acts in vitro to releaes ACTH from dispersed rat anterior pituitary cells. In using a genomic library, the human urocortin has been cloned and localized to human chromosome 2. It has also been discovered that both human and rat urocortin share 95% identity within the mature peptide region.
Literature Reference:C.J. Donaldson et al., Endocrinology, 137, 2167 (1996)
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