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UROC-002A
Urocortin, rat
Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
Size:0.5mg
P1(RMB):644
MW:4707.4
One letter sequence:DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2
Molecular Formula:C206H338N62O64
Description:Peptide that is more potent than CRF at binding and activating type-2 CRF receptors and shares ~95% sequence with human version. As a mammalian neuropeptide related to fish urotensin and corticotropin-releasing factor, it also serves as an inducer of c-Fos in regions enriched in type-2 CRF receptors.
Literature Reference:J. Vaughan et al, Nature, 378, 287(1995)
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