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NEUP-012B
Neuropeptide S (rat)
Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Val-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln Trifluoroacetate salt
Size:1mg
P1(RMB):1089
MW:2210.53
One letter sequence:SFRNGVGSGNKKTSFRRAKQ
Molecular Formula:C95H160N34O27
Description:This peptide is a modulator of arousal and possibly anxiety-related behaviour. It acts by activating its cognate receptor (NPSR) and inducing mobilization of intracellular Ca2+. Central administration of NPS induced wakefulness and reduced slow wave and REM sleep in rats. These peptides represent potential lead compounds for the treatment of sleep and anxiety disorders.
Literature Reference:Y.-L.Xu et al., Neuron, 43, 487 (2004) N.Okamura and N.K.Reinscheid, Stress, 10, 221 (2007) K.Domschke et al., Mol. Psychiatry, 16, 938 (2011)
Cas:412938-75-1
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